The reason we learn how to take pictures manually is because cameras are made to make a well balanced photo, but most of the time you won't want such a vanilla effect, instead, when adjusting manually, the photo can be almost anything.
First Setting: Shutter Speed
A faster shutter speed leaves out blur or motion, while slower shutter speeds create blurred fluid photos.
This changes a photo because the slower the shutter speed, the more undefined and abstract the photo is.
Second Setting: Aperture
Aperture is used to control how bright your photo is, a larger or wider aperture makes your photo brighter, while a smaller aperture makes your photo darker. The trick is to find a good balance for the conditions the photo is being captured in.